@conference {361,
	title = {Design and Simulation of flow field for sinusoidal scaffold using Computational fluid dynamics},
	booktitle = {XXIX Congress of International/Japanese Society of Biomechanics},
	year = {2023},
	month = {08/2023},
	publisher = {International Society of Biomechanics},
	organization = {International Society of Biomechanics},
	abstract = {<p>Bone can heal small defects by itself but fails to do so in case of severe bone damage. A common treatment for severe damage is grafting bone. Approximately 1.6 million bone grafts are performed in the United States per year [1]. Unfortunately, this treatment has several serious drawbacks, such as a high risk of infections or even donor site morbidities. Tissue Engineering and regenerative medicine is a promising biomedical alternative to cure severe bone damage. Scaffolds can be used to re-build the bone structure since they can support seeded cells and provide an optimal environment for cell growth [2]. The scaffold{\textquoteright}s geometry design influences flow characteristics, mass transfer rates, and wall shear stress (WSS). The WSS is an important parameter to investigate because it affects the differentiation and bioactivity of cells inside the scaffold. In this work, we investigate the influence of the scaffold geometry on the flow field, WSS and mass transport using computational fluid dynamics (CFD). The reliability of the numerical results is evaluated using the μ-particle image velocimetry (PIV) method.</p>
},
	keywords = {3D printing, CFD, OpenFOAM, Scaffold geometry, scaffolds, Wall shear stress},
	author = {Theresia Baumgartner and Markus B{\"o}senhofer and Olivier Guillaume and Aleksandr Ovsianikov and Michael Harasek and Margit Gf{\"o}hler}
}
@conference {362,
	title = {How do sinusoidal scaffolds affect fluid flow-induced wall shear stress and mass transport?},
	booktitle = {28th Congress of the European Society of Biomechanics },
	year = {2023},
	month = {07/2023},
	publisher = {European Society of Biomechanics},
	organization = {European Society of Biomechanics},
	abstract = {<p>Bone is one of the most transplanted tissues. About 1.6 million bone grafts are performed each year only in the United States [1]. This treatment has serious drawbacks, such as a higher risk of infections or even donor site morbidities. Therefore, an alternative is the use of scaffolds to create bone tissue. The role of scaffolds in bone tissue engineering is to mimic the native bone tissue and is used to provide a template that supports seeded cells to get an optimal environment for their proliferation [2] to re-build the damaged structure. Hence, an optimal scaffold design is important and must be found because even small changes in the geometry of the pore network of the scaffold influences the process of cell growth and mechanical properties [2,3]. Wall shear stress (WSS) has a significant role in the differentiation of cells, especially for bone. Even minor changes in the flow field, especially near the wall regions, can directly affect cell bioactivity. Therefore, in this work, we use computational fluid dynamics (CFD) simulations to investigate the WSS and the effect of the flow rate on mass transport rates in scaffolds. The numerical results were compared to {\textmu}-particle image velocimetry (PIV) experiments to evaluate the reliability of the CFD method.</p>
},
	keywords = {bone tissue, CFD, PIV, scaffolds, Wall shear stress},
	author = {Theresia Baumgartner and Markus B{\"o}senhofer and Olivier Guillaume and Aleksandr Ovsianikov and Michael Harasek and Margit Gf{\"o}hler}
}
